金媛媛 微生物代谢工程研究室 副研究员

教育背景及工作经历：

2022.10 –至今 中国医学科学院医药生物技术研究所 副研究员

2014.09-2022.09 中国医学科学院医药生物技术研究所 助理研究员

2011.09-2014.07 天津医科大学 博士

2006.09-2009.07 河北大学 硕士

主要研究方向：生物大分子和细胞类物质的活性及成药性研究

专业研究领域：1.鉴定和筛选各种生物活性的生物大分子，通过原核和真核表达体统进行制备和活性评价，并结合计算机辅助药物设计，进行理性设计和优化；2.来源于脐带血造血干细胞的天然杀伤细胞和树突状细胞的培养体系优化，生物活性表征和临床应用的研究。

代表性论文：

1.Rui‑fang Zheng†, Kaderyea Kader†, Di‑wei Liu, Wen‑ling Su, Lei Xu, Yuan‑yuan Jin* and Jian‑guo Xing*. A network pharmacology approach to decipher the mechanism of total flavonoids from Dracocephalum Moldavica L. in the treatment of cardiovascular diseases. BMC Complementary Medicine and Therapies. 2024,24:15.

2.Lihua Cui#, Yuanyuan Jin#, Sen Zou, Jing Xun, Xiangyang Yu, Qi Zhang*, Zhaoyong Yang*. The antitumor activity of hPRDX5 against pancreatic cancer and the possible mechanisms. BRAZ J MED BIOL RES(Q2) 2022; 55: e12324.

3.Xiao Feng, Shuai Fan, Guangxin Lv, Maocai Yan, Guangteng Wu, Yuanyuan Jin*, Zhaoyong Yang*. Expression, purification and X-ray crystal diffraction analysis of alcohol dehydrogenase 1 from Artemisia annua L. Protein Expression and Purification 2021, 187:105943.

4.Yuan-yuan Jin#, Wen-zhuo Yang#, NK cells adjuvant therapy shows survival benefits in a gastric mixed signet ring cell carcinoma patient: A case report. Medicine 2021, 100(10): e24979.

5.Yuying Ji#, Rui Cao#, Guangxin Lv, Yuanyuan Jin*, Jing Chen*, Identification of Functional Fragments in gMYL6 and the Mechanism Exploration in Improving NK Cell-Mediated Cytotoxicity. Iran J Immunol. 2020; 17(4): 292-302.

6.Yuan-yuan Jin#, Wen-zhuo Yang#, Sen Zou, Zheng-yang Sun, Chun-tao Wu, Zhao-yong Yang, Chemoradiotherapy combined with NK cell transfer in a patient with recurrent and metastatic nasopharyngeal carcinoma inducing long-term tumor control. Medicine 2020, 99(43):e22785.

7.Zou S, Liu J, Sun Z, Feng X, Wang Z, JinY*, YangZ*. Discovery of hPRDX5-based peptide inhibitors blocking PD-1/PD-L1 interaction through in silico proteolysis and rational design. Cancer Chemother Pharmacol 2020,85(1):185-193.

8.Juanjuan Liu#, Yuanyuan Jin#, Xiaozhou Feng, Sen Zou, Guangxin Lv, Zhifei Zhang*, Zhaoyong Yang*. Solubility-enhanced gMYL6 fused with a hexa-lysine tag promotes the cytotoxicity of human NK cells. Immunology Letters 2018, 198: 66-73.

9.Linhu Li#，Yuanyuan Jin#，Bin Wang, Zhaoyong Yang, Mingliang Liu, Huiyuan Guo, Jun Zhang, Yu Lu. A Structure-based Strategy toward the development of novel candidates for antimycobacterial activity: Synthesis, biological evaluation and docking study. Chem Biol Drug Des 2018, 91(3):769-780.

10.Yuanyuan Jin#，Ya-dong Li#，Wan Sun，Shuai Fan，Xiao-zhou Feng，Kang-youWang，Wei-qing He*，Zhao-yong Yang*. The whole-cell immobilization of D-hydantoinase-engineered Escherichia coli for D-CpHPG biosynthesis. Electronic Journal of Biotechnology 2016, 21, 43-48.

11.Mei-Yan Wang#, Yuan-Yuan Jin#, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry 2015, 103, 91-104.

12.Xiaodong Liu, Yuanyuan Jin, Zheng Cui, Koichi Nonaka, Satoshi Baba, Masanori Funabashi, Zhaoyong Yang, Steven G. Van Lanen*. The Role of a Nonribosomal Peptide Synthetase in L-Lysine Lactamization During Capuramycin Biosynthesis. ChemBioChem 2016, 17(9):804-810.

13.Xiaodong Liu, Yuanyuan Jin, Wenlong Cai, Keith D. Green, Anwesha Goswami, Sylvie Garneau-Tsodikova, Koichi Nonaka, Satoshi Baba, Masanori Funabashi, Zhaoyong Yang* and Steven G. Van Lanen*. A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW. Org Biomol Chem 2016, 14, 3956-3962.

授权专利：

1. 一种脐血源NK细胞的体外扩增培养方法及其制备试剂盒（杨兆勇、金媛媛、韩强、孙正阳、杨文卓、樊帅、王忠博、刘坤），专利号 ZL202111208066.6，授权日 2023年3月24日

2. 一种具有抗肿瘤活性的多肽IMB-P1及其应用（杨兆勇、刘娟娟、金媛媛、樊帅、陈静、张志斐、孙正阳），专利号 ZL201810070903.5，授权日 2022年2月11日

3. 一种洋橄榄叶素衍生物的制备方法（杨兆勇、金媛媛、刘玉凤、王保国、樊帅、吕广新、张倩），专利号 ZL202011146085.6 授权日 2021年10月22日

4. 一种靶向PD1/PDL1相互作用的抗肿瘤活性多肽IMB-P6及其应用（杨兆勇、金媛媛、刘娟娟、樊帅、张志斐、孟浩毅）专利号 ZL201810070905.4 授权日 2021年9月24日

5. 一种具有增强脐血来源NK细胞杀伤活性的多肽及其应用（杨兆勇、姬钰滢，金媛媛，陈静，邹森，樊帅，王忠博，石北辰，孙正阳）专利号 ZL202010139042.9 授权日 2021年9月24日

6. 洋橄榄叶素衍生物在制备抗肿瘤药物中的应用（杨兆勇、刘玉凤、金媛媛、王保国、樊帅）专利号 ZL202010993616.9 授权日 2021年8月6日

7．一种具有抗肿瘤作用的宿主因子hPRDX5、编码基因及其应用（杨兆勇，金媛媛，邹森，樊帅，冯晓，吕广新，王忠博，张琦）专利号 ZL201910434270.6 授权日 2020年11月13日

联系电话：15311515153

电子邮箱：jinyuanyuan@imb.pumc.edu.cn