Microbial and Biochemical Pharmacy —— Microbiology
Department：Laboratory of Microbial Pathway Engineering
Education & Research Experience
2021/03 – Now Assistant Professor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
2019/09 – 2021/02 Research Associate, Department of Chemistry, The University of British Columbia
2014/05 – 2019/09 Postdoctoral Research Fellow, Department of Chemistry, The University of British Columbia
2012/07 – 2014/05 Research Associate, State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2007/09 – 2012/06 Ph.D. in Bioorganic Chemistry, State Key Laboratory of Bioorganic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2003/09 – 2007/07 B.Sc. in Chemistry, Tianjin University
Research Field：Total biosynthesis of synthetic drugs and biocatalysis
Based on the biosynthetic pathways as well as enzymatic reactions discovered in natural product biosynthesis, Dr. He’s lab will focus on the pathway engineering for total biosynthesis, through the methods of synthetic biology and combinatorial biosynthesis. They will also devote to protein engineering and evolution to develop new biocatalysts for drug synthesis.
1. Hai-Yan He, and Katherine S. Ryan*. Glycine-derived Nitronates Bifurcate Between O-Methylation and Denitrification in Bacteria. Nat. Chem. 2021, doi: org/10.1038/s41557-021-00656-8.
2. Hai-Yan He, Alyssa C. Henderson, Yi-Ling Du, and Katherine S. Ryan*. Two-Enzyme Pathway Links L-Arginine to Nitric Oxide in N-Nitroso Biosynthesis. J. Am. Chem. Soc. 2019, 141, 4026–4033.
3. Hai-Yan He, Man-Cheng Tang, Feng Zhang, and Gong-Li Tang*. Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis. J. Am. Chem. Soc. 2014, 136, 4488–4491.
4. Hai-Yan He, Hua Yuan, Man-Cheng Tang, and Gong-Li Tang*. An Unusual Dehydratase Acting on Glycerate and a Ketoreductase Stereoselectively Reducing a-Ketone in Polyketide Starter Unit Biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315 –11319.
5. Long-Fei Wu#, Hai-Yan He#, Hai-Xue Pan, Li Han, Renxiao Wang, and Gong-Li Tang*. Characterization of QmnD3/QmnD4 for double bond formation in quartromicin biosynthesis. Org. Lett. 2014, 16, 1578-81. (# These authors contributed equally to this work.)
6. Hai-Yan He#, Hai‐Xue Pan#, Long‐Fei Wu, Bei‐Bei Zhang, Han‐Bo Chai, Wen Liu, and Gong‐Li Tang*. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line. Chemistry & Biology 2012, 19, 1313–1323. (# These authors contributed equally to this work.)