Microbial and Biochemical Pharmacy
Department：National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Education & Research
2007/9 – Now Assistant research professor and associate research professor in the Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences. I got the qualification of research professor at 2020。
2004/9-2007/7 ph.D in Institute of Medicinal Biotechnology & Chinese Academy of Medical Sciences.
2004/9-2007/7 Master in Foundation Research Institute &Shandong Academy Medical Sciences.
2004/9-2007/7 Bachelor in Department of biology & Shandong Normal University.
Discovery of anti-fungal and anti-bacterial antibiotics and the pharmacological study of antibiotics
I have been engaged in discovery and research of anti-Gram negative bacteria antibiotics targeting outer membrane synthesis and pharmacology of anti-fungal antibiotics
Representative articles in the field of antibiotics published （the first and corresponding authors）in recent years：
(1)Lin,Yuan#; Li,Yan#; Zhu,Yuanjun; Zhang,Jing; Li,Yongzhen; Liu,Xiao; Jiang,Wei;Yu,Shishan; You,Xuefu; Xiao,Chunling; Hong,Bin; Wang,Yanchang*; Jiang,Jiandong*; Si,Shuyi*. Identification of novel anti-tuberculosis agents that target ribosome subunit interaction using yeast two-hybrid system. PNAS, 2012,43(109): 17412 -17417.
(2)Wang,Weiwei; Liu,Chao; Zhu,Ningyu; Lin,Yuan; Jiang,Jiandong; Wang, Yanchang; Li,Yan*; Si,Shuyi*. Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10.ACTA PHARMACEUTICA SINICA B, 2018, 5(8):772-783.
(3)Xuelian Zhang#; Yan Li#; Weiwei Wang; Jing Zhang; Yuan Lin; Bin Hong; Xuefu You; Danqing Song; Yanchang Wang; Jiandong Jiang*; Shuyi Si*. Identification of an anti-Gram-negative bacteria agent disruption the interaction between lipopolysaccharide transporters LptA and LptC. Int J Antimicrob Agents, 2019, 53(4):442-448.
(4)Li,Yan#; Zhu,Xiaohong#; Zhang,Jing; Lin,Yuan; You,Xuefu; Chen,Minghua; Wang,Yanchang; Zhu,Ningyu*; Si,Shuyi*. Idengtification of a Compound That Inhibitis the Growth of Gram-Negative Bacteria by Blocking BamA-BamD Interaction. Frontiers in Microbiology,2020,11.
(5)Li,Yan#; Sunhong Min#; Zhu,xiaohong; Bian,Cong; Wang,Yangchang*; Si,Shuyi*. Identification of New Antifungal Agents Targeting Chitin Synthesis by a Chemical-Genetic Method. Molecules, 2019,24(17).
(7)Yunyu Chen, Xiayi Niu, Yan Li*, Xiaoping Liu*. Development of an ELISA-based high throughput screening method for novel anticancer agents targeting β-catenin/Lef1 interaction. Chin J Biotech, 2019, 34（4）: 707-717.
Awards and Honors
2013 Satoshi ōmura award of Institute of Medicinal Biotechnology.
2017 Second prize of the Second Micro Class Teaching Competition of Institute of Medicinal Biotechnology.