Name：WANG Yanxiang

Department：Department of Organic Chemistry

Tel: (8610) 63033012

Email:wangyanxiang@imb.pumc.edu.cn

Education & Research Experience

2019/09 – Now Professor, Doctoral Supervisor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2013/09 – 2019/09 Associate Professor, Master Supervisor, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2014/01– 2015/12 Research Fellow, Department of Pharmacy, University of Georgia, USA

2010/09 – 2013/09 Research Assistant, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

2005/09 – 2010/07 Ph.D. in microbial and biochemical pharmacy, Peking Union Medical College

2001/09 – 2005/07 Bachelor in pharmacy, XiangYa Medical College

Research Field：

Chemical Biology, medicinal chemistry, pharmacology

Research Interests：

Dr. Wang has been engaged in chemical biology related to anti-infection, anti-inflammation and metabolic disorder. The team mainly focused on design, synthesis and characterization of biological functional molecules such as small molecular probes, activity screening, mechanism of action study, targets exploration, validation, as well as biology and pharmacology research work such as signaling pathway studies.

Selected Publications

[1] Zeng QX, Pang J, Fan TY, You XF, Tang S, Wang YX*, Song DQ*. Berberine directly targets the NEK7 protein to block the NEK7–NLRP3 interaction and exert anti-inflammatory activity. J. Med. Chem. 2021, 64, 768–781.

[2] Yang YS^#, Lu, X^#, Zeng, QX, Pang, J, Fan, TY, You, XF, Tang S, Wang YX*, Song DQ*. Synthesis and biological evaluation of 7-substituted cycloberberine derivatives as potent antibacterial agents against MRSA. European journal of medicinal chemistry. 2019; 168: 283-292.

[3] Zeng QX^#, Pang J^#, Fan TY, You XF, Tang S, Wang YX*, Song DQ*. Synthesis and biological evaluation of berberine derivatives as a new class of broad-spectrum antiviral agents against Coxsackievirus B. Bioorg Chem. 2020 95:103490.

[4] Wang YX^#, Pang WQ^#, Zeng QX, Deng ZS, Fan TY, Jiang JD, et al. Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1. European journal of medicinal chemistry. 2018; 143: 1858-1868.

[5] Fan TY^#, Wang, YX^#, Tang, S, Hu, XX, Zen, QX, Pang, J, et al. Synthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents. European journal of medicinal chemistry. 2018; 157: 877-886.

[6] Yang YS^#, Wei W^#, Hu XX, Tang S, Pang J, You XF, Fan TY*, Wang YX*, Song DQ. Evolution and Antibacterial Evaluation of 8-Hydroxy-cycloberberine Derivatives as a Novel Family of Antibacterial Agents Against MRSA. Molecules. 2019; 24.

[7] Fu HG^#, Li, ZW^#, Hu, XX, Si, SY, You, XF, Tang S*, Wang YX*, Song DQ.Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents. Molecules (Basel, Switzerland). 2019; 24.

[8] Wang YX^#, Yang, L^#, Wang, HQ, Zhao, XQ, Liu, T, Li, YH, et al. Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy. Molecules. 2018; 23.

[9] Tang S^#, Li, YH^#, Cheng, XY, Yin, JQ, Li, YH, Song, DQ*, Wang YX*. Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents. Medicinal chemistry. 2018; 14: 764-772.

[10] Liu X^#, Wang, Y^#, Yun, P, Shen, X, Su, F, Chen, Y, et al. Self-assembled filomicelles prepared from polylactide-poly(ethylene glycol) diblock copolymers for sustained delivery of cycloprotoberberine derivatives. Saudi pharmaceutical journal. 2018; 26: 342-348.

[12] Wang YX^#, Liu, ZD^#, Bi, CW, Liu, L, Deng, HB, and Song, DQ. How can tricyclic sophoridinic derivatives be used as autophagy inhibitors for cancer treatments? Future medicinal chemistry. 2017; 9: 835-837.

[13] Wang YX^#, Liu, L^#, Zeng, QX, Fan, TY, Jiang, JD, Deng, HB, et al. Synthesis and Identification of Novel Berberine Derivatives as Potent Inhibitors against TNF-alpha-Induced NF-kappaB Activation. Molecules (Basel, Switzerland). 2017; 22.

[14] Tang S, Peng, ZG, Li, YH, Zhang, X, Fan, TY, Jiang, JD, Song, DQ*, Wang YX*. Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents. Chemistry Central journal. 2017; 11: 94.

[15] Gang Ren*, Yan-Xiang Wang*, Ying-Hong Li, Dan-Qing Song, Wei-Jia Kong, Jian-Dong Jiang. Structure-activity relationship of berberine derivatives for their glucose-lowering activities. Int J Clin Exp Med 2017;10(3):5054-5060.

Awards and Honors

[1] Science and Technology Award of Chinese Pharmaceutical Association, Second Prize, 2019.

[2] Science and Technology Award of Chinese Pharmaceutical Association, Second Prize, 2016.

[3] Young Scientist Innovation Forum of Chinese Academy of Medical Sciences and Peking Union Medical College, Second Prize, 2019.

Academic Appointments

Youth Editor of Chinese Journal of Antibiotics